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doi: 10.1016/J.CPCARDIOL.2024.102721 43 AkilLAnwar AhmadH

The therapeutic utility of native GLP-1 is limited by its rapid degradation [2], primarily mediated by dipeptidyl peptidase-4 (DPP-4) and secondarily by neutral endopeptidases (NEPs) and renal clearance [3, 4]

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Glucagon-like peptide-1 (GLP-1) receptor agonists, a new class of drugs sold under names such as Ozempic, Wegovy, and Zepbound, are soaring in popularity for their ability to achieve and sustain substantial weight loss and improve cardiometabolic health

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