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His summary of the general results applies to the discussion above: poor replicability of genetic association studies, conclusions have become less straightforward than initially imaginedthere is no binary yes/no association or influence on painand subsequent studies after the initial have reported no association, or sex-dependent association, or significant associations but of different single nucleotide polymorphisms or haplotypes, and significant associations, but of different phenotypes than those initially suspected

Acknowledgements This study was financed by the Ministry of Science and Technology (Taiwan) (107-2321-B-002-017, 108-2321-B-002-035, 107-2321-B-002-039, 108-2321-B-002-051, 109-2314-B-002-064-MY3, and 110-2628-B-002-046)

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Pathogenic Angiogenic Mechanisms in Alzheimers Disease, in Physiologic and Pathologic Angiogenesis Signaling Mechanisms and Targeted Therapy , ed