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Treatment starts at the lowest dose and is gradually increased every four weeks to help the body adapt and minimise side effects

Acta 1758 , 17431750 (2006)

Eur J Microbiol Immunol

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5% due to alternative cytochrome P450 depending glutathione (GSH) conjugation pathway At high doses : Glucuronidation and sulfation pathways become saturated Cytochrome P450 dependent pathway becomes now more important.With depletion of hepatic glutathione, hepatotoxic, reactive, electrophilic metabolites are formed

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