Further, ebselen follows the analogous catalytic steps as that of native GPx enzymes, and the activation energies for the ebselen-catalyzed and native enzyme-catalyzed GPx reactions are 55 kJ/mol and 36.5 kJ/mol, respectively [78]
Further, DSePA, being a diselenide, can participate in the GPx cycle either by undergoing oxidation to seleninic acid by hydroperoxides (pathway I) or by undergoing reduction to selenol through thiols (Pathway II)
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To make sure we are on the same page, altruistic Mom, is the metaphorical GSH, and the ROS is her child who dropped the ice cream