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It plays a reno-protective role by reducing Ang II levels (193)

Implicated mechanisms include upregulation of molecular pathways involved in oxidative stress, aberrant calcium signaling, silencing of transcription factors and histone deacetylases, and deregulation of cytoskeleton-associated proteins

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TNIP1/ANXA6 and CSMD1 variants interacting with cigarette smoking, alcohol intake affect risk of psoriasis