About 50-75%, up to 85% of people discontinue GLP-1s within 2 yearsoften due to cost, side effects, or preference
Long-term maintenance after completing dose escalation Once you reach your target maintenance dose and complete the initial adaptation period, the dose schedule enters its long-term phase
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Retatrutide Phase 2 reported 4%, matching placebo
Prioritizing protein helps preserve (or grow) lean muscle mass (especially important on a calorie reduction), maintain strength, and support healthy aging during weight loss
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