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According to the ALF Study Group in the United States, APAP-associated toxicity contributes to approximately 46% of all cases of ALF in adults, which far exceeds idiosyncratic drug-induced liver injury (DILI) by more than fourfolds (Ostapowicz et al., 2002

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The most recent consensus statement from the International Microdialysis Forum, released in 2015, summarized key advances in the CMD clinical usage and contributions to neurocritical care since 2004 [25]

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