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Research Evidence: Studies, including a randomized controlled trial published in Clinical, Cosmetic and Investigational Dermatology, have shown that oral glutathione (500 mg daily) taken over 8-12 weeks can result in noticeable improvement in melasma severity compared to placebo

Cobalt supplementation may be required in some areas where Vitamin B12 deficiency occurs

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Qi Y, Wang J, Bomben VC, Li DP, Chen SR, Sun H, et al

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However, emerging evidence suggests that tocotrienols may possess even greater antioxidant potential due to their unique structure, which allows them to interact with lipid membranes more effectively and modulate inflammatory pathways [117]