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Clinical trials have demonstrated its safety and effectiveness, and the FDA has approved it for weight management
Importantly, these medications carry a boxed warning for risk of thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), and are contraindicated in patients with personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2
J Comp Neurol 526(9):14191443
Section 5.9 of the label, Acute Gallbladder Disease, reports that in placebo-controlled trials cholelithiasis occurred in 1.5% and 0.4% of patients treated with Ozempic 0.5 mg and 1 mg respectively, and was not reported in placebo-treated patients
Both are manufactured by Novo Nordisk and distributed through standard pharmaceutical supply chains