is glp-1 for diabetes GLP-1-based therapies type 2 diabetes: from single, dual and triple agonists to endogenous production and L-cell differentiation | Diabetology & Metabolic Syndrome GLP-1R and Diabetes

Drucker, a fellow in Habeners lab in the 1980s, outlined the processing of proglucagon and the biology of GLP-1 action on insulin-producing cells, which led to the development of multiple types of treatments for type 2 diabetes

This matters more during weight loss, when you are relying on a smaller amount of food and supplements to cover your needs

A qualitative synthesis of findings revealed dermatological patterns and trends related to various GLP-1RA treatments

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Nat Rev Endocrinol (2012) 8(12):72842

(Left) In liver cells, GLP-1 can mediate cholesterol efflux by acting directly on LXR, or by inducing an increase in ATP-binding cassette transporter A1 (ABCA1) mRNA through Ca2+/calmodulin (CaM)-dependent protein kinase kinase/CAM-dependent protein kinase IV/Prolactin regulatory element binding (CaMKK/CaMKIV/PREB), increasing apolipoprotein AI (apo AI) mRNA and promoter expression, and increasing apo AI secretion, thereby mediating intracellular cholesterol efflux