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The 2015 Pickart review in BioMed Research International documents placebo-controlled trials showing GHK-Cu facial creams reduce fine lines and wrinkle depth, improve skin laxity and density, and increase dermal keratinocyte proliferation across 12-week protocols in women with mild-to-advanced photoaging [9]

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Effectiveness of concomitant treatment experienced by study participants is included in Table 3

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If injections provoke disproportionate pain, evaluate placement , tissue plane , and possible nerve irritation