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Note that Ser15-phospho-p53 foci are excluded from the nucleus after treatment with 25 mM FOXO4-DRI for 3 days

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1 Introduction Multiple Sclerosis (MS) is a chronic, immune-mediated, demyelinating disease of the central nervous system (CNS) that affects 2.8 million people world-wide ( Relapsing-onset MS has a strong female prevalence, which is thought to be a result of females having more robust T cell-mediated autoimmunity [reviewed in ( 2 Male sex is associated with more rapid progression and CNS tissue loss in MS 2.1 Neurological progression and cognitive decline are more rapid in males with MS There is strong evidence that males are more prone to neurological deterioration than females with MS

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