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The triggering of macrophage inflammatory pathways is also a critical event in lesion development
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This pause was intentional and designed to support and sustain balloon efficacy after the initial phase, allowing the Semaglutide to be reintroduced after balloon removal in the seventh and eighth months to consolidate weight loss and support behavioral change
Whether this unique pattern worsens the obese state or constitutes a favorable adaptation remains unclear, and the physiological and pathophysiological implications of the altered GH/IGF-I axis in obesity remain uncertain with GH neither being the cause nor the solution to reverse obesity
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