A post hoc analysis of the phase IIb trial showed that tirzepatide was associated with a reduction in the level of high-sensitivity ICAM-1, CRP, and YKL-40 after 26 weeks of treatment in a dose-dependent manner [83, 103]
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The drugs active ingredient, tirzepatide, has also been used off-label to treat obesity
L-arginine 11 pooled randomized trials, average 5.4 mmHg systolic reduction
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