Secondary signals across both trials reduced knee osteoarthritis pain, fewer obstructive sleep apnea events, improvements in triglycerides, blood pressure, LDL, and hsCRP suggest systemic metabolic remodeling rather than simple caloric suppression
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Ceftriaxone in association with azithromycin should be used as first-line treatment, alternatively ceftriaxone can be substituted with cefixime while doxycycline is an alternative to macrolides [152]
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