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Thus, the transient nature of estrogen elevations in female rats may limit estrogens facilitatory effects on GLP-1 signaling, potentially explaining the more robust disruption of alcohol discrimination observed in males

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Zakrzewska-Pniewska B, Gawel M, Szmidt-Salkowska E, Kepczynska K, Nojszewska M

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[27] Unlike many other antioxidants, melatonin can cross cellular membranes freely and access intracellular compartments, including mitochondria, where it may help protect against oxidative damage

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