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Additional differential enrichment analysis found that proteins related to the mitophagy pathway, such as Sqstm1, Bnip3, Map1lc3b, and Optn, were significantly upregulated, suggesting an increase in mitochondrial damage

That was the point when things started to feel real

PMID: 41904760 Antioxid Redox Signal D-Allulose Regulates Obesity via Endoplasmic Reticulum Stress-Mediated Glucagon-Like Peptide-1 Receptor Pathway

The combined data showed a greater than 200% increase in GLP-1, exceeding the initially reported 140% increase

Despite increased weight gain, UKPDS found that insulin monotherapy decreased the incidence of microvascular complications