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10.1016/j.cmet.2016.09.006 20

Molecular Formula: CHN (as cation) Molecular Weight: 159.21 g/mol (free base) CAS Number: 1220-83-3 Mechanism: Selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in the methylation of nicotinamide and regulation of NAD+ precursor availability and cellular energy metabolism Sequence Classification: Small-molecule quaternary ammonium compound Purity Analysis: 98% by HPLC This molecular data supports advanced research into NNMT inhibition, NAD+ biosynthesis pathways, adipogenesis, and metabolic homeostasis studies

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1b, Extended Data Fig