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86 Combining lactulose with PEG might be helpful, which was assessed in a non-inferiority trial that randomized 40 patients with cirrhosis and HE to receive either lactulose alone (2030 g orally or 200 g enema) or a similar dose of lactulose plus PEG (280 g in 4 L of water orally as a single dose in 30120 m)
Larger vials exist, but the 5mg format reduces waste if a protocol needs to be adjusted mid-course, and it keeps reconstituted solution within its optimal stability window before a new vial is needed
Increased frequency, where you feel the need to urinate much more often than usual but pass only small amounts each time
The mean age was 31 years (range: 13 to 57 years), 49% were women, 90% White, 4% Asian, and 6% other
In addition to its outstanding glucose-lowering effect, DPP-4i have also shown non-metabolic functional activities, including anti-inflammatory effect and cardiovascular protection, particularly with regards to BP regulation
doi: 10.1016/j.chom.2022.06.011 223 TschuckJPadmanabhan NairVGalhozAZaratieguiCTaiHMCiceriGet al
