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Interestingly, while Ex4(2-39) retains high affinity and full activity at 10 nM, the replacement of Asp 9 with Glu resulted in the complete loss of efficacy, despite no effect upon affinity (Montrose-Rafizadeh et al ., 1997), suggesting that Asp 9 plays an important role in activity

Poor hygiene does not cause HS

In such cases, discontinuation may be necessary, and alternative treatment options should be discussed

The cycle becomes more stable, ovulation is more likely to return, and thus the chance of pregnancy increases

However, this response is highly individual

Common side effects may include: Mild: Nausea, vomiting, diarrhea, fatigue, constipation Less Common: Acid reflux, dizziness, stomach pain Rare but Serious: Pancreatitis, gallbladder issues The good news is that side effects are usually mild and temporary