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Compounded GLP-1 Market Context and Competitive Landscape The compounded GLP-1 weight loss market has expanded rapidly as consumers look for alternatives to FDA-approved medications that often come with high retail pricing and limited insurance coverage

On the other hand, the most abundant DPP-IV-processed metabolite GLP-1 (9-36) NH2 , has also been reported to have biological activities, protecting human aortic endothelial cells and cardiomyocytes in vivo in dogs (137) and ex vivo in mice (138) and rats (139), even in the absence of a GLP-1 Receptor (140, 139)

demonstrated GHS-R1a mRNA expression in GLUTag and NCI-H716 cells (30)

they may actively support heart health

Unlike older medications that target a single hormone, Mounjaro is the first and only dual incretin receptor agonist , meaning it stimulates both GLP-1 and GIP receptors in the body to improve metabolic function