We found that both male and female GPR146-deficient mice exhibited significantly reduced circulating FFA levels compared to control littermates (Fig
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Particularly, it was recently demonstrated in a large multiethnic study that the GPx3 loci was strongly associated with a similar motor neuron disease, ALS, perhaps identifying a risk locus for neuronal disease susceptibility 20,38
Molecular mechanism of Cyss-regulated NRF2 expression Next, we investigated the molecular mechanism by which Cyss regulates NRF2 expression