GLP-1R binds to ligands to internalize GLP-1R, and can independently reduce TG accumulation in hepatocytes by activating key signaling molecules downstream of insulin receptor substrate 2 (IRS2)
The liver plays a central role in metabolizing and eliminating excess hormones
Although endogenous GLP-1 lowers blood glucose levels, it is degraded quickly, which results in loss of its hypoglycemic effects
Additionally, L-carnitine exhibits antioxidant properties, supports cardiovascular function, and may improve insulin sensitivity
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