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Indeed, further studies have shown that, unlike apoptosis, caspase-3 is not crucial for eryptotic cell death [84]

doi: 10.2165/00003088-199120020-00004

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Eryptosis and aging Multicellular organisms are subject to the biological process of aging, and recently 12 different hallmarks of aging have been defined: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, dysregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis [415]

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