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These weight losses are even more pronounced in people who are obese but do not have diabetes (Figure 5)

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This alteration results in downregulation of IFN- and IL-2 expression, leading to an increased risk of infections [320]

Oral semaglutide, which provides comparable benefits in HbA1c reduction and weight loss to injectable GLP-1 receptor agonists, is a valuable non-injectable alternative to consider before progressing to injectables

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