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Tirzepatide and retatrutide, which have dual agonist activities targeting both GLP-1 receptor and GIP receptor (GIPR) or GLP-1 receptor and glucagon receptor (GCGR), respectively, have been shown to improve energy expenditure and metabolic flexibility in other studies [50, 51]

Oral supplementation (50150 g daily) may suit dietary deficiency without nerve involvement, but malabsorption cases require injections

Prog Neurobiol 62:649671 Dunn WB, Bailey NJC, Johnson HE (2005) Measuring the metabolome: current analytical technologies

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The potential cost of using a compromised solution is immense