Endpoints frequently measured include the activity of alkaline phosphatase (ALP), an early marker of osteoblast differentiation, the expression of the master osteogenic transcription factor Runx2, and the deposition of a mineralized matrix, which can be visualized with Alizarin Red staining
The Crem knockout ( Crem -/- ) mice, this upregulation is abolished in germ cells, while somatic expression of CYP51A1 remains unaffected
Eur J Clin Pharmacol 74 , 147160 (2018)
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Elevated concentrations of N-homocysteinyl-lysine isopeptide in acute myocardial infarction: links with ADMA formation
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