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reported that kaempferol increased mitochondrial membrane permeability and elevated cytoplasmic cytochrome c levels in HT-29 cells

Neurol Sci 39(10):1677

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The severity of tau pathology in AD, is usually assessed using Braak staging, a neuropathological classification that traces the spread of neurofibrillary tangles from the transentorhinal region in early stages (III), to the limbic areas (IIIIV), and finally to the neocortex in the most advanced stages (VVI) [86]