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A 28-week study showed that the 15mg dose produced an average body weight loss of 7.38 percent compared to 2.28 percent with placebo
[4] The second activation step takes place predominantly in the kidneys where 1-hydroxylase converts 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D (calcitriol), an active secosteroid hormone that binds nuclear receptors in enterocytes, osteoblasts, renal tubules, parathyroid cells, and numerous immune and endocrine cells to modulate hundreds of genes involved in calcium-phosphate homeostasis, skeletal remodelling, and immunoregulation
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But the sheer volume of rodent studies (over 100 at this point) paints a remarkably consistent picture, and the anecdotal reports from bodybuilders and athletes line up pretty closely with what the science predicts
Pharmacol Biochem Behav 2022;220:173463
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These studies are anticipated to open new therapeutic avenues and advance our understanding of the immune systems complexity, potentially leading to revolutionary breakthroughs in cancer therapy
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