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Even if solution appears clear and colorless throughout the 30-day period, microbiological growth or chemical breakdown may be occurring invisibly

The mechanism appears to be a combination of pre-meal volume (the fruit fills the stomach), insulin modulation through naringenin (a flavonoid found in grapefruit), and a small calorie offset from displacing other food

Stanley TL, Falutz J, Marsolais C, et al

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PMID: 30343833