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Each 10C increase roughly doubles reaction rates, which is why refrigeration (versus room temperature) dramatically extends shelf life

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In the U.S., the cost of treating diabetic neuropathy alone is nearly $11 billion every year (Foundation for Peripheral Neuropathy, 2025)

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Maintaining prebiotic fiber intake can buffer some of this effect and supports the gut microbiome diversity that keeps GLP-1 receptor signaling functioning properly

The total cost, including ongoing charges and potential add-on treatments, must be carefully evaluated