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Chalk et al

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In the field of obesity, efforts are underway to use multi-omics and clinical data to predict individual responses to weight-loss interventions (including GLP-1RAs) and to precisely predict the risk of side effects (e.g., nausea) using algorithms like Phenomix GRS

This is the thing we're always told about lifestyle is that it quote unquote doesn't work, it's too hard, people all go back

Clinical trials show that around one in ten people are non-responders

Excessive ROS damages mitochondrial DNA (mtDNA), proteins, and lipidsfurther impairing ETC function in a vicious cycle