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J Neurosci 24:15311540 Cai X, Shen YL, Zhu Q, Jia PM, Yu Y, Zhou L, Huang Y, Zhang JW, Xiong SM, Chen SJ, Wang ZY, Chen Z, Chen GQ (2000) Arsenic trioxide- induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia

If side effects are intolerable despite dietary modifications, dose reduction or temporary treatment interruption may be necessary, with subsequent slower re-titration once symptoms resolve

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By the 1970s, rapid growth in drug spending led health plans to spin off pharmacy benefits into the PBM industry