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Manage complications on a case-by-case basis, e.g.: Complications [1] [2] Inflammatory Small bowel diverticulitis (most common complication of jejunoileal diverticulosis) [1] Peritonitis (due to gastrointestinal perforation) Abscess formation Hemorrhage (most common complication of duodenal diverticulosis) [1] Mechanical bowel obstruction due to, e.g.: Enterolith formation and impaction Volvulus Intussusception Stricture or adhesions from prior inflammation Compression (e.g., resulting from a distended diverticulum) Nonmechanical bowel obstruction (e.g., from intestinal dyskinesia) Small intestinal bacterial overgrowth leading to, e.g.: Malabsorption Nutritional deficiencies (e.g., vitamin B 12 deficiency and fat-soluble vitamin deficiencies ) Anemia Pancreaticobiliary disorders (associated with periampullary diverticula) Benign pneumoperitoneum Small bowel diverticulitis Definition [1] [2] The inflammation of one or more small bowel diverticula (most commonly jejunoileal diverticula) Caused by stasis of contents within the diverticulum, resulting in venous outflow obstruction and infection Epidemiology [3] Typically affects older adults Most common complication of jejunoileal diverticulosis Etiology [1] [2] [3] Obstruction of the diverticulum due to, e.g.: Predisposing factors include: Foreign body Cholelithiasis Diverticular ulceration Blunt trauma Clinical features [1] [2] [3] Presentation is often nonspecific and can mimic other causes of an acute abdomen
However, in my experience after many years of prescribing oral semaglutide, people have varying ability to fit the dosing regimen into their daily lives consistently
Incretin-based treatments for T2D and obesity result in improved glucose-dependent insulin secretion, appetite suppression, and delayed gastric emptying, thereby leading to improved glycemic control and bodyweight reduction [7]
In the short term, microglial activation is a protective response
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