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In the present study, we established a rat model of -cell failure using LOsG and found that high glucose promoted PSC activation and proliferation to enhance pancreatic fibrosis
This study was supported by National Key R&D Program of China (2023YFC2509100), Science and Technology Commission of Shanghai Municipality (23Y31900400), National Natural Science Foundation of China (82370984 & 82370980), Natural Science Foundation of Shanghai (22ZR1437600), Shanghai's Top Priority Research Center (2022ZZ01017), and Dominant disease biological sample project of the Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (YBKA202201)
J Am Pharm Assoc (Wash) 41 , 437447 (2001)
Specifically, these drugs act as glucagon-like peptide-1 (GLP-1), which regulates hunger by communicating with the brain to produce certain levels of insulin and lower blood sugar
