The mean BMI was 33.1 kg/m 2
Hormonal pulses during sleep stages: Hormone release follows circadian rhythms, and estrogen may drop more sharply during certain sleep phases
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Observed side effects in research settings are generally mild and may include temporary nausea-related observations, flushing-related observations, headache-related observations, fatigue-related observations, administration-site irritation, pigmentation variability, pigmentation variability involving freckles or moles, and temporary appetite-related response variability depending on research amount, UV exposure, administration frequency, skin type, and individual physiological sensitivity
However, progression to fibrosis also occurs in patients with steatosis alone [7], although rates of progression and overall mortality rates are increased in NASH [1, 8]
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