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With its localization to the SR, nNOS regulates the S-nitrosylation of the calcium release channels, the type 2 ryanodine receptors (RYR2) resulting in release of stored calcium, The localization of nNOS in the plasma membrane allows for direct S-nitrosylation of L-type Ca 2+ channels resulting in increased influx of calcium

In this study, the APP-treated serum was analyzed through proteomics profiling and 59 DEPs were identified compared with control group

These macrophages secrete MMP-13 and ADAMTS-5, degrading type II collagen

B12 plays an important role for the body, it is crucial for the formation of red blood cells, energy production, metabolism and for maintaining a healthy nervous system

The role of the gut microbiota and microbial metabolites in neuroinflammation

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