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GLOW may be the more logical choice when the research question concerns the shared trio and fewer experimental variables are preferred

These results indicated that gingerols and shogaols have immunomodulatory activity by decreasing the production of COX-2 and proinflammatory cytokines and the release of histamine, and they reduced the severity of inflammatory disorders

Silva YP, Bernardi A, Frozza RL

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Additionally, these are not components of FDA-approved drugs and have not been found safe and effective for any condition. The A4PCs guidance leaves no room for interpretation on this point

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