retatrutide glp-1 gip glucagon agonist Pharmacotherapies under investigation based on a combination of Retatrutide: The GLP-1/GIP/Glucagon Triple-Agonist Guide

Muscle Loss Risk Increases (Major Concern) GLP-1 users already risk: low protein intake low calorie intake rapid weight loss lean tissue loss Add nightly alcohol and you get: impaired muscle protein synthesis lower testosterone (men) reduced growth hormone increased cortisol reduced recovery Result: More muscle loss Less fat loss Softer look Slower metabolism This is one of the biggest physiological downsides

Current GLP-1 use by age is reported in KFF's writeup of the poll

Harach T, Pols TW, Nomura M, Maida A, Watanabe M, Auwerx J, Schoonjans K

Log in Hops Herb Pharm 30 Milliliters $N/A (MSRP) Already have an account

Unlike commercially manufactured medications, compounded semaglutide is not FDA-regulated

[7] It is well established that low muscle mass and muscle strength are associated with a higher risk of all-cause mortality and disability