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Extended IGF1 LR3 use may affect endogenous IGF-1 production through feedback mechanisms involving growth hormone secretion

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Chokshi, M.D., from the University of Tennessee Campbell Clinic in Memphis, and colleagues examined the association between the time of last Ozempic dose and anesthesia complications in patients who underwent total hip or knee arthroplasty from January 2018 to January 2023

A Phase 2 trial found IGF-1 levels plateaued at month 6 despite continued daily dosing, suggesting partial desensitization of the GH-IGF-1 axis under constant stimulation

Glucagon-like peptide-1 receptor agonists and risk for gastroesophageal reflux disease in patients with type 2 diabetes: a population-based cohort study