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Product Care Store unopened vials at 20C25C (68F77F) Protect from excessive heat and direct light Maintain sterile handling during research use Intended Use This product is intended exclusively for qualified laboratory researchers

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Up to 80 percent of the expected lean mass loss was avoided in some arms 4

Mechanistically, MSU crystal-induced inflammatory gouty flares are caused by the activation of pyrin domain-containing protein 3 inflammasome (NLRP3) with consequent IL-1 secretion from macrophages and neutrophils, resulting in acute inflammatory responses, intense pain and joint swelling [28]