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In the medulla, an elevated UA concentration results in the deposition of urate precipitates and the activation of the Nod-like receptor protein 3 (NLRP3) inflammasome

doi: 10.1016/j.bbr.2017.03.032 234 MaskeryMGouldingEMGenglerSMelchiorsenJURosenkildeMMHolscherC

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Structural and functional abnormalities of the primary somatosensory cortex in diabetic peripheral neuropathy: a multimodal MRI study

The only evidence is experimental: your research outcomes stop aligning with published data, or dose-response curves flatten unexpectedly