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-Patients taking Wegovy had an average weight loss of 14.9% after 68 weeks 1 -Patients who took Saxenda had between 5 and 10% weight loss compared with placebo after 56 weeks 2 Medically supervised weight management with GLP-1 prescriptions or refills available online Most GLP-1 side effects are associated with mild abdominal discomfort

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7 Evidence gaps and future perspectives The present review has extensively examined, through highlighting the many preclinical and clinical studies, the mechanisms underlying endothelial dysfunction and hypertension and the current conventional and innovative therapeutic strategies to counteract them

Follow local disposal guidelines for medications, and consider using a sharps container for needles and syringes