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The exact mechanisms through which activation of THR improves MASH are still unclear but are known to control fat synthesis, regulate fatty acid oxidation, regulate cholesterol metabolism, improve mitochondrial function, and reduce inflammation and fibrosis

When GLP-1R is activated, microglial activation is suppressed, reducing the levels of VEGF and other cytokines involved in neovascularization

GLP-1 receptor agonists such as semaglutide can help manage blood glucose, body weight, and certain cardiometabolic risks when prescribed for an appropriate patient

Most women normalize within three to six months

The New England Journal of Medicine, 389 (10), 877888

Campins L, Camps M, Riera A, Pleguezuelos E, Yebenes JC, Serra-Prat M