the major CVOTs included significant numbers of patients with coronary artery disease and provide compelling evidence for MACE reduction with GLP-1RAs
GLP-1 class safety monitoring should include awareness of these important risks: Pancreatitis : Patients should promptly report severe abdominal pain, with or without vomiting Gallbladder disease : Report symptoms of biliary colic or cholecystitis Acute kidney injury : Maintain adequate hydration, especially if experiencing nausea/vomiting Hypoglycemia : Increased risk when used with insulin or sulfonylureas Suicidal ideation : For patients using Wegovy or Zepbound, monitor for mood changes Patients should be counseled to report any neck swelling, difficulty swallowing, persistent hoarseness, or palpable thyroid nodules, as these warrant evaluation regardless of GLP-1 use
They are similar in how you take them but differ in their mechanism
By contrast, compounded options generally cost around $200 a month
For safety, see the peptide safety guide
The consequences ripple outward through every system in your body