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When glutathione synthesis or recycling becomes impeded, the resulting redox imbalance initiates a cascade of oxidative damage that disproportionately affects the vascular endothelium and cardiometabolic systems

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In the body, Citrulline converts to the amino acid arginine, which then converts to nitric oxide

Four patients in the tolebrutinib group and no patients in the placebo group experienced ALT increases to more than 20 ULN, all within 90 days of the first treatment dose

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