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Increased WAT "beiging" (7-fold increase in UCP1 & 3.5-fold increase in PRDM16 expression) and other energetic futile cycles (SERCA, lipids) that increase energy expenditure

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Like any medication, GLP-1based medications may cause side effects in some individuals

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84,367 The involvement of the CNS opens new avenues for research and the development of novel therapeutic targets aimed at modulating central pain pathways in DPN (Fig