Rhodes, C.J
Trader sentiment reflects uncertainty around whether formal Category 1 placement occurs before or after that meeting, given the distinction between removal from Category 2 and affirmative listing, as well as ongoing questions about manufacturing standards and clinical evidence thresholds
Elimination of VPA follows first-order kinetics, with a half-life ranging from 5 to 20 hours (mean 11 hours)
As we discussed in the CY 2026 OPPS/ASC proposed rule (90 FR 33792 through 33793), and in agreement with commenters, we continue to believe that requiring the median, 10th percentile, and 90th percentile allowed amounts will provide greater context and clarity with respect to the payer-specific negotiated charge than the estimated allowed amount
Notably, in animals primed with L-dopa + BZ, MPE alone mitigated DID severity
changes in laws and regulations applicable to natural health products, consumer wellness products, drug development, and advertising
