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The lack of dose-finding studies complicates clinical decision making

The study found faster wound closure rate and a higher percentage of ulcer healing with all three GHK-Cu treatment groups over placebo, however, the 0.3% group demonstrated the fastest closure rate and highest percentage of ulcer healed compared even to the higher 3% strength treatment

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The addition of L-arginine (50 mg/kg i.g.) to L-NNA (20 mg/kg i.p.) in rats treated with PTX (10 mg/kg i.p.) resulted in similar decrease of IL-1 level to that recorded in rats given PTX alone without L-arginine administration ( Fig