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Gradual dose escalation a strategy already employed with approved agents such as semaglutide and tirzepatide appeared to support tolerability

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P., Ajabiya, J., Teli, D., Bojarska, J., & Apostolopoulos, V

It was showed that a GLP-1 analogue with improved half-life in a NEP 24.11 degradation assay had prolonged action in mice, therefore making this assay relevant to evaluate the potential efficacy in vivo of our compounds 40

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Primary and Secondary Endpoints The primary endpoints for TRIUMPH-1 follow the standard FDA framework for obesity drug approval